Version 0.343 have performance optimizations. Version 0.371 have multiple weathers system, please download helper plugin as described in readme file. Version 0.395 have underwater caustics which require enbhelperse.dll plugin (also used for weather system).
Highly recommended TES Skyrim bug fix of game objects like fire, water particles, doors, vegetables, candles, etc is available here
Also you can edit parameters to your own taste inside integrated editor (display it by pressing SHIFT and ENTER keys together, by default). Modification do not have graphic preset, by default it's ugly unconfigured (unless specified in description of version), so you need to download such presets made by users, feel free to visit my forum or Nexus site for them.
Also memory manager is not required as Skyrim SE is 圆4 and there is no 4 gb memory limit. Version dublicates the most features of the old Skyrim ENBSeries modification with as much compatibility between presets as possible, except external shaders which differ because of specific differencies between DX9 and DX11.